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Bipolar Aging and Imaging Study

We were interested in finding out how the structure and function of the brain changes with age among individuals with bipolar disorder compared to those changes seen in people without bipolar disorder. Our study investigated how brain characteristics related to performance on cognitive tests and real-world functioning.We also learned about how each person’s genetic information may relate to the way that his or her brain responds during thinking.

Publications associated with this study:
  • McKenna BS, Drummond SP, Eyler LT. Associations between circadian activity rhythms and functional brain abnormalities among euthymic bipolar patients: A preliminary study. J Affect Disord. 2014 Aug; 164:101-6.
    View in: PubMed
  • McKenna BS, Sutherland AN, Legenkaya AP, Eyler LT. Abnormalities of brain response during encoding into verbal working memory among euthymic patients with bipolar disorder. Bipolar Disord. 2014 May; 16(3):289-99.
    View in: PubMed
  • McKenna BS, Eyler LT. Overlapping prefrontal systems involved in cognitive and emotional processing in euthymic bipolar disorder and following sleep deprivation: a review of functional neuroimaging studies. Clin Psychol Rev. 2012 Nov; 32(7):650-63.
    View in: PubMed 
  • Dev, S.I., McKenna, B.S., Sutherland, A.N., Liu, T.T., Shin, D.D., Wierenga, C.E & Eyler, L.T. (2015). Increased cerebral blood flow associated with better response inhibition in bipolar disorder. Journal of International Neuropsychological Society. In Press.

  • McKenna, B.S., Theilman R., Sutherland, A.N., & Eyler, L.T. Fusing fMRI and DTI Modalities to predict Working Memory and Processing Speed Performance among Euthymic Bipolar Patients. Journal of the International Neuropsychological Society, Under Third Review.